“From Tappuah the border went along westward.” The author has now gone back up to the north-central border of Ephraim very close to Michmethath and is describing the northern border as it goes to the west. Tappuah (or En-tappuah; the spring of Tappuah) is mentioned as being on the southern border of Manasseh in Joshua 17:7-8. The northern border is easy to follow at some places because it followed the valley of the “brook of Kanah,” which flows toward the Mediterranean Sea.
“the sea.” This is the Mediterranean Sea.