“I will not listen.” It is very important that God’s people realize that God does not hear prayers simply because people pray. Everyone sins, but some people are stubborn and unrepentant about their sin. A person’s heart must be right in the sight of God for the prayer to be effective. For example, if a man treats his wife badly it will hinder his prayers (1 Pet. 3:7). It is the prayer of a righteous person that accomplishes much (James 5:16). There are a number of verses that say God does not answer the prayers of the wicked (cp.Job 35:12-13; Prov. 15:29; Isa. 1:15; 59:1-2; Ezek. 8:17-18; Micah 3:4; Zech. 7:12-13; and James 4:3). [For more on God not hearing the prayers of the wicked or honoring their sacrifices, see commentary on Amos 5:22].
“Your hands are full of blood.” The people’s actions in their day-to-day life showed that their supposed worship of God was insincere and hypocritical.