“after the 62 weeks.” Jesus Christ will be killed at the end of the 69th week, after, or at the very end of, the 62nd week.
“Anointed One.” That is, the Messiah (see commentary on Dan. 9:25).
“cut off.” This phrase is commonly used for being put to death, which Jesus Christ was. It is used of the death of the Messiah in Isaiah 53:8.
“and will have nothing.” The Hebrew text reads, “and there is nothing to him,” which is exactly what happened to Jesus Christ when he died. He got nothing of what we would expect with the death of the Messiah and a king. He died as a criminal and his body was treated as if he was a criminal, and he was not even buried in a family tomb, but in a borrowed tomb of a non-family member. After he was buried and the tomb shut, Nicodemus came and buried him with spices, but even his family and closest disciples did not know that had happened. When Jesus died, “he had nothing,” as this text in Daniel says.
[For more on his family and disciples not knowing he was buried with spices, see commentary on John 19:40].
“the ruler who will come.” This ruler that will come is the Antichrist, though he is not often called that in the Bible.
“the city and the sanctuary.” That is, the city of Jerusalem and the temple in it. There will be a temple built again before Jesus builds the temple portrayed in Ezekiel, which he will do early on in his Millennial Kingdom. The materials for building that temple have already been gathered together in Israel. That is the temple spoken of in Revelation 11:1-2, and the temple into which the Antichrist, “the man of sin,” enters to show he is God to the people (2 Thess. 2:4).
“Desolations are determined. This statement is not connected to any one specific “desolation,” and the fact that the verb is plural means it refers to more than one desolation. There is no reason to believe that these desolations do not involve the city of Jerusalem, the Temple (the “sanctuary” of Dan. 9:26), people at the time of the Antichrist’s rule (cp. Dan. 9:27), and even the Antichrist himself (cp. Keil & Delitzsch, Commentary on the Old Testament).