“came up…a little one.” Daniel 7:8 shows us that the antichrist will have a small and unimpressive beginning, but he will grow (thus “came up”) and eventually have more power than all the other horns. We learn more about the Antichrist by his parallel, his type, who is Antiochus Epiphanes, who is also called a little horn in Daniel 8:9-12.
“eyes like the eyes of a man.” The “eyes” and “mouth” of this little horn alert us to the fact that this is a person, not a kingdom. In the biblical culture, “eyes” were a primary instrument of learning, and in this context the fact that the little horn had eyes like a man points to both humanity and intelligence and insight. The antichrist will be smart and cunning.